Partner 1 – University of Twente – The Netherlands
General description: At the University of Twente, the department of Biomaterials Science and Technology research is focused on synthesis, structure-properties relationships in polymeric materials and their application in medicine. Through purposeful design of the chemical structure and architecture of the polymer tailored materials for use in a specific envisaged (medical) application can be prepared.
Expertise: The department is headed by Prof. Dr. Dirk W. Grijpma. The synthesis and properties of polymers and the preparation of composites is a central issue in his current research. Ongoing work is aimed at the development of advanced microstructures by photo-polymerization of functionalized degradable oligomers. Other researches are on the tissue engineering of bone and blood vessels, and the synthesis and processing of polymers for medical devices. A main topic at the moment is the development of hybrid materials based on synthetic and natural components, and their processing into biologically active structures using advanced stereolithographic techniques.
Role in the project: Within the RAPIDOS project the Department of Biomaterials Science and Technology of the University of Twente prepares composite photocurable resins based on biodegradable poly(trimethylene carbonate) macromers and bone forming calcium phosphate (CaP) ceramics. In addition microparticles are loaded with osteogenic Icaritin and added to the resins. From these composite resins designed scaffolding structures with optimal pore network characteristics for cell culturing and integration with bone tissue are prepared. For this, use is made of the (clinical) imaging data obtained from other partners.
Key personnel: Professor Dirk W. Grijpma is head of the department of Biomaterials Science and Technology, at the University of Twente, and also holds a part-time position at the University Medical Center Groningen. The department has been involved in large European Union funded programs (STREP PROTEC, FP6 STEPS), and Prof. Grijpma has coordinated several large national programmes in the Netherlands and a large spearhead programme of the University of Twente on advanced microstructures.