Partner 2 – AOForschungsInstitut Davos – SWITZERLAND
General description: The AO Forschungs Institut Davos (AOF) is part of the AO Foundation, a medically guided not for profit organisation specialized in the treatment of trauma and disorders of the musculoskeletal system. Its global research expertise encompasses cell therapy, tissue engineering, imaging, biomechanic including cadaveric wet anatomical laboratory, infection research and experimental surgery.
Expertise: At the AOF, the Human Morphology service and the Computed Tomography (CT) Imaging group are focusing on developing state of the art procedures and methods for CT imaging analysis and visualization, computerized planning and development. The Musculoskeletal Regeneration Program develops biological approaches addressing pathologies of the musculoskeletal system, with a particular focus on bone, cartilage and disc tissues. The ultimate goal is to define strategies for prevention of degenerative disorders of the skeleton and to re-establish its functionality. At the AOF, the Preclinical service offers expertise and develops animal models to answer questions from academic researchers, clinicians and industrial partners to improve fracture fixation devices and surgical procedures.
Role in the project: The AOF contribution to the RAPIDOS project is first on the development of computed X-ray tomography (CT) data analysis and computer knowledge to elaborate a fitting CT image workflow to obtain optimal relevant data for rapid prototyping or solid freeform fabrication, secondly on the preparation of polymeric hydrogel as embedding matrix for stem cells in combination with printed calcium phosphate ceramic and polymer composites developed by partners for bone defect repair. Furthermore, the AOF brings its strong expertise on in vitro and ex vivo (bioreactor) bone/cartilage study that will be valuable for the screening of the consortium solutions. The AOF brings also its capability and knowledge of small and large animal models.
Key personnel: Prof. Geoff Richards, Director of the AO Research Institute Davos (AOF). Prof. Mauro Alini, Deputy Director of the AO Research Institute Davos, Head of the Musculoskeletal Regeneration Program. Dr. David Eglin, Leader of the Polymers and Surface Focus Area.