Partner 6 – Shanghai Key Laboratory of Orthopaedic Implants, Shanghai Jiao Tong University – CHINA
General description: Shanghai Key Laboratory of Orthopaedic Implants (SJTU), Department of Orthopedic Surgery, Shanghai Ninth People‘s Hospital, Shanghai Jiao Tong University School of Medicine is an influential R&D center of orthopedic implants and training base in China. Headed by Academician Dai Kerong, Academician of Chinese Academy of Engineering, the lab owns an academic research team comprised of orthopedic surgeons, biological scientists, engineers and technicians, featuring its cross-disciplinary research in medicine and engineering. Meanwhile, the Orthopedic Department of Shanghai Ninth People‘s Hospital is currently supported by the program of State Key Discipline, National Clinical Key Specialty, National “211 Project” Key Discipline, Shanghai Clinical Medical Center of Joint Surgery and Key Discipline of Shanghai Education Commission.
Expertise: The lab has been actively carrying out clinical-oriented orthopedic translational studies, which focus on the optimization design and application of customized prosthesis, stem-based therapy for bone and cartilage repair, development and biological evaluation of novel bone substitutes, mechanism and prevention of periprosthetic osteolysis, osteoporosis and osteoarthritis, bone tumor and metastasis, etc. Major achievements in bone regeneration include the development and application of bioreactor for bone tissue engineering, using BMSC based BMP-2 gene medicine to promote the bone repair, successful clinical trial on stem cell enrichment technology to promote spinal fusion.
Role in the project: In the RAPIDOS project, the SJTU focus on the development of cell therapies using stem cells and their assessment in vitro and in vivo based on scaffolds developed within the consortium.
Key personnel: Prof. Ting-ting Tang, MD, PhD, Director of Shanghai Key Laboratory of Orthopaedic Implants and associate Chairman of Department of Orthopaedic Surgery. He is chairman of China development committee of the International Chinese Hard Tissue Society (ICHTS), the board member of Chinese Association of Biomaterials. He also served as the editorial member of 15 international and Chinese journals, including Calcified Tissue Int, Journal of Orthopaedic Surgery & Research, Chinese Journal of Traumatology (English Edition). His research focus on the stem cells based therapy for bone repair, development and evaluation of new orthopaedic implants and biomaterials. Dr. Qi-ming Fan, senior researcher in Shanghai Key Laboratory of Orthopaedic Implants, who is specialized in stem cells research. Dr. Hong-Iue, orthopaedic surgeon in Shanghai Ninth People’s Hospital, who is specialized in trauma surgery and focus on the treatment of bone defects and osteomyelitis.