Resume of the RAPIDOS scientific report 2013-2014:

In this 1.5 year period, the RAPIDOS project partners have developed a clinical CT imaging
process technology workflow for development of anatomically relevant and precise custommade
macro-structured designed scaffolds. The goal of this workflow is to allow the surgeons
to design and self-assess patient specific implants taking into account the constraints of the
biomaterial and fabrication process.
The optimisation of composite formulations; poly(trimethylcarbonate)/calcium phosphate and
poly(lactic-co-glycolic)/tricalcium phosphate/magnesium (PLGA/TCP/Mg) respectively, for
stereolithography and low temperature rapid manufacturing is in progress and already implant
scaffolds could be fabricated by both stereolithography and low temperature rapid
prototyping. Biodegradable polymeric nanofibers and microspheres loaded with icaritin, a
Chinese medicine phytomolecule as potential drug delivery vehicle have been prepared for
incorporation into the photo-polymerisable resin formulation for stereolithography. In vitro
and in vivo studies have shown the osteopromotive effect of icaritin loaded into scaffolds, and
magnesium was shown to influence biofilm formation onto the surface of PLGA/TCP/Mg
To date, the RAPIDOS project activities have led to 2 peer-review manuscripts and the filling
of 1 patent. Two workshops were organised and attended by European and Chinese partners.
Finally, the RAPIDOS results have contributed to the creation of one Spin-off company for
production of new biomaterials.