The 6th Meeting of the RAPIDOS Chinese- European Joint Research project

Pr. Dirk Grijpma organized the 6th meeting of Rapidos Consortium in the Campus of the University of Twente (The Netherlands) on Tuesday afternoon, the 14th of June 2016. 6th Rapidos meeting hold in Twente This meeting was organized one day before the conference AFPM (Advanced Functional Polymers for Medicine), hold at the Drienerburght hotel, of the same Campus.

First, Dr. David Eglin welcomed all the members and proposed the agenda of the working day.

Then, Xi Zhang (PhD candidate at the Queen Mary University of London) presented his last work regarding the mechanical enhancement of PTMC composite membranes by incorporation of nano-fibers. His developed technology brings advantages as drugs carrier, because pharmaceutics can be actually loaded within those nano-fibers and then be integrated in PTMC implants, without any risk of denaturation.

Following Xi’s presentation, another PhD student from the University of Twente, Mike Geven, gave us an update on patient specific implants for orbital floor reconstruction. His is currently preparing the work-flow allowing to fabricate implants using stereolithography from CT data for the next in vivo study on sheep model. Additionally, he reported his recent advances in loading PTMC/HA scaffold with Chinese medicine (i.e. icariin and icaritin) using coating versus bulk incorporation, in order to enhance bone development.

Pr. Yuan Huipin followed Mike’s presentation, regarding the utilization of ceramic-based scaffolds loaded with icaritin, for the formation of bone. He gave a summary of the different animal studies they have performed over the last few years using such scaffolds, and correlated those in vivo results with in vitro findings on similar scaffolds. They showed that controlling the loading charge of icaritin in ceramic construct is critical in order to optimize osteogenic effect and to promote bone formation under both in vitro and in vivo condition.

Finally, Dr. Guillaume Olivier, research scientist at the AO Research Institute, presented the potential of PTMC mixed with HA for bone repair. Indeed, they have demonstrated that scaffolds made by stereolithography, containing PTMC with HA, clearly improved bone healing compared to PTMC only. Further work in currently undertaken in order to assess the suitability of such implant for the regeneration of damaged orbital floor.

For the second part of the afternoon, the Chinese partners presented their final reports for Rapidos project. Dr. Xinluan Wang (SIAT) talked about the in vivo efficacy of the newly developed scaffolds made of PLGA + HA endowed with antibacterial compounds (modified chitosan). Such bi-functional scaffold represents great candidate as implant for bone tissue regeneration able as well to prevent bacterial infection.

To end up this session, Dr. David Eglin listed the last deliverable deadlines and introduced other possible international collaborations between China and Europe.

Important: Pr. Qin Ling is proud to announce the next Rapidos meeting (taking place in Xi’an, China the 20th of September 2016), combined with the International Combined Orthopaedic Research Societies conference (i-CORS, 21-25 of September 2016). More information available on the i-CORS website.