The 7th Meeting of the RAPIDOS Chinese- European Joint Research project + iCORS 2016

Pr. Qin Ling organized the 7th meeting of Rapidos Consortium in the Xi’an International Conference Center (China) on Tuesday afternoon, the 21st of September 2016.

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First, Pr. Qin Ling welcomed all the members, followed by Dr. David Eglin who proposed the agenda of the working day.

Then, Dr. Lai Yuxiao (Associate Professor at the Shenzhen Institute of Advanced Technology, SIAT) gave an update regarding their scientific production in terms of publications (15 accepted manuscripts), patents (5 filled patents) and numerous presentations in international conferences.

Following, Pr. Tingting Tang (Professor at the Shanghai Jiao Tong University, SJTU) presented their recent results regarding the antibacterial scaffolds based on modified chitosan and based on magnesium, in order to treat bone infection.

The last Chinese partner (301 Military Hospital, Beijing) was represented by Dr. Wang Cheng who talked about the characterization of clinical osteonecrosis undertaken in their institute, followed by the innovative extracellular cartilage-based microtissue strategy examined under in vitro and in vivo models, aiming to regenerate damaged cartilage.

For the second part of the morning, three different European partners have presented their works. First, Xi Zhang (PhD student from the Queen Mary University of London, QMUL) developed composite films made of PTMC (polytrimethylene carbonate) reinforced with nanofibers of polylactic acid (PLA). Those composite films exhibit interesting mechanical properties, shape-memory behavior and have the great potential to be used as drug reservoir. Some of the preliminary data have already been accepted for publication in Material Communication Today (Polymer-polymer composites for the design of strong and tough degradable biomaterials, Vol. 8 Sept. 2016) and were presented in a poster at the World Biomaterials Conference, in May 2016 in Montreal (Canada).

Following Xi’s presentation, another PhD student from the University of Twente, Mike Geven, gave us an update on patient specific implants for orbital floor reconstruction. His is currently preparing the work-flow allowing to fabricate implants using stereolithography from CT data for the next in vivo study on sheep model. This study will validate in pre-clinical animal model the benefice of PTMC/nanohydroxyapatite patient specific implant for reconstructing orbital floor defects.

Finally, Dr. Guillaume Olivier (research scientist at the AO Research Institute, Davos Switzerland), presented the potential of PTMC mixed with HA for bone repair. Indeed, they have demonstrated that scaffolds made by stereolithography, containing PTMC with HA, clearly improved bone healing compared to PTMC only. Further work is currently undertaken in order to assess the efficacy of icaritin loaded PTMC/HA scaffolds to promote the repair of bony defects. This work resulted in several oral presentations (i.e. WBC in Montreal in May 2016, eCM in Davos in June 2016 and iCORS in Xi an in September 2016) and in one published manuscript (Poly(trimethylene carbonate) and nano-hydroxyapatite porous scaffolds manufactured by stereolithography, in Polymer for Advanced Technologies, August 2016).

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This meeting was followed by the 2016 International Combined Meeting of Orthopedic Research Societies (iCORS, organized by Pr. Qin Ling) where several members of the Rapidos consortium had the possibility to present their results either during oral presentations or poster sessions. One specific Rapidos workshop was organized by Prof. Geoff Richards and Dr. David Eglin (from AO Research Institute Davos, Switzerland) dealing with 3D-printing for bone substitutes. The goals of this workshop were to offer a discussion platform for scientists and surgeons to separate the hype and reality of 3D printing technology for bone graft substitutes, assess the translational potential of AM technology combined with biological effectors in the field of bone graft substitutes and identify the key issues and important future research directions for translation into the clinic.

Group-Photo of all the participants of the iCORS 2016 taking place in Xi'an, China (September 21st- 24th).

Group-Photo of all the participants of the iCORS 2016 taking place in Xi’an, China (September 21st- 24th).

This year’s iCORS meeting has attracted over 500 abstracts with about 800 participants from 32 countries. There were 35 workshops, over 200 oral presentations and 80 plus poster presentations.

The details of 2016 ICORS-Xian meeting including history of ICORS meeting, details of each member ORS society and supporting organizations, meeting program, details of workshops, abstracts, etc. can be found at the Journal of Orthopaedic Translation (Volume 7, October 2016, Proceedings of the 2016 International Combined Meeting of Orthopaedic Research Societies) website at:
http://www.sciencedirect.com/science/journal/2214031X/7

At the end of the ceremony, Dr. Olivier Guillaume (AO Research Institute Davos) was recompensed by the Best Paper Recognition Award of the iCORS 2016.

Next meeting will be organized by Pr. Joost de Bruijn (XPAN Biotechnology BV, the Netherlands) in spring 2017.