The 8th Meeting of the RAPIDOS Chinese- European Joint Research project

The 8th Meeting of the RAPIDOS Chinese- European Joint Research project.

Pr. Joost de Bruijn organized the 8th meeting of Rapidos Consortium in XPAND Biotechnology BV located in Bilthoven (The Netherlands), on Friday 10th of March 2017.
Group photo of the European partners involved in Rapidos project, taking place in XPAND (Bilthoven).
From left to right: Prof. Richards, Prof. De Bruijn, Prof. Alini, Dr. Yuan, Prof. Peijs, Dr. Barbieri, Dr. Eglin, Prof. Grijpma, Mr. Geven, Mr. Chang and Dr. Guillaume.

First, Pr. De Bruijn welcomed all the European members, followed by Dr. David Eglin who proposed the agenda of the working day.

Then, Xi Chang (PhD candidate at the QMUL, UK) gave an update regarding their work recently published in Materials Today Communications (Polymer-polymer composites for the design of strong and tough degradable biomaterials). They have developed hybrid polymer-polymer structures, which exhibit enhanced mechanical properties compared to conventional polymeric films. Additionally, he showed that the photo-polymeric resin can be loaded with therapeutics integrated into nano-carriers (PLA electrospun nano-fibers) before UV-crosslinking, without any risk of degradation and interaction with the photo-crosslinkable polymers. Such results are of high relevance as they open the field of bioactive scaffolds fabricated using photo-reaction, such as stereolithography, loaded with photosensible drugs.

Following, Mike Geven (PhD candidate at the University of Twente, The Netherlands) gave us an update on patient specific implants for orbital floor reconstruction.
His is currently investigating the degradation kinetic of the implants made of PTMC/nanohydroxyapatite under in vivo-mimicking condition (with different enzymes). In a recent publication, the authors have developed PTMC/HA scaffolds using stereolithography, on which they have observed a segregation phenomenon occurring during the fabrication process (Surface-Enrichment with Hydroxyapatite Nanoparticles in Stereolithography-Fabricated Composite Polymer Scaffolds Promotes Bone Repair. Acta Biomaterialia). This phase segregation results in a surface enrichment of HA particles, covering the PTMC printed scaffold, with a potent biological osteogenic reaction in vitro and in vivo.
Mike Geven is trying to control the parameters influencing this self-corralling behavior and to optimize the HA repartition within 3D printed scaffolds.

After this presentation, Dr. Guillaume O (from AO Research Institute) presented the preliminary outcomes of the large animal study performed at the AO foundation. The aim of this research is to investigate the utilization of novel patient specific implant made of degradable PTMC/HA for orbital floor repair, as alternative to the commonly used titanium mesh. We hypothesize that PTMC/HA will promote bone reconstruction of the damaged orbital floor area and will better fit the anatomical defect compared to bioinert titanium meshes.

Finally, Dr. David Barbieri (from XPAND Biotechnology BV) introduced their new product development based on a putty paste, easily administrable to any orthopedic defects and aiming to stimulate bone ingrowth due to intrinsic osteoinductive activity.

For the second part of the meeting, Dr. David Eglin informed the different partners to the next deliverables to achieve, the managerial activities of Rapidos project and the next deadlines. He proposed to organize to last meeting of this project during the TERMIS-EU conference, taking place in Davos (26-30th of June 2017).

More information are available on TERMIS web-site here.
European Chapter Meeting of the Tissue Engineering and Regenerative Medicine International Society 2017